Military risk factors for Alzheimer's disease. Issue 4 (1st July 2013)

• Record Type: Journal Article
• Authors: Weiner, Michael W.; Friedl, Karl E.; Pacifico, Anthony; Chapman, Julie C.; Jaffee, Michael S.; Little, Deborah M.; Manley, Geoffrey T.; McKee, Ann; Petersen, Ronald C.; Pitman, Roger K.; Yaffe, Kristine; Zetterberg, Henrik; Obana, Robert; Bain, Lisa J.; Carrillo, Maria C.
• Is Part Of: Alzheimer's & dementia. Volume 9:Issue 4(2013)
• Page Start: 445
• Page End: 451
• Publication Date: 2013-07-01
• Subjects: Alzheimer's disease -- Risk factors -- Military medicine -- Traumatic brain injury -- Posttraumatic stress disorder -- Tau -- Beta‐amyloid -- Apolipoprotein E e4 -- Biomarkers -- Alzheimer's Disease Neuroimaging Initiative -- Vietnam -- Veterans -- Chronic traumatic encephalopathy -- Blast injury; Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1016/j.jalz.2013.03.005
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: Traumatic brain injury (TBI) and post‐traumatic stress disorder (PTSD) are signature injuries of the wars in Iraq and Afghanistan and have been linked to an increased risk of Alzheimer's disease (AD) and other dementias. A meeting hosted by the Alzheimer's Association and the Veterans' Health Research Institute (NCIRE) in May 2012 brought together experts from the U.S. military and academic medical centers around the world to discuss current evidence and hypotheses regarding the pathophysiological mechanisms linking TBI, PTSD, and AD. Studies underway in civilian and military populations were highlighted, along with new research initiatives such as a study to extend the Alzheimer's Disease Neuroimaging Initiative (ADNI) to a population of veterans exposed to TBI and PTSD. Greater collaboration and data sharing among diverse research groups is needed to advance an understanding and appropriate interventions in this continuum of military injuries and neurodegenerative disease in the aging veteran.