Depressive symptoms predict incident dementia during short‐ but not long‐term follow‐up period. (14th February 2014)

• Record Type: Journal Article
• Authors: Mirza, Saira Saeed; de Bruijn, Renée F.A.G.; Direk, Nese; Hofman, Albert; Koudstaal, Peter J.; Ikram, M. Arfan; Tiemeier, Henning
• Is Part Of: Alzheimer's & dementia. Volume 10(2014)Supplement 5
• Page Start: S323
• Page End: S329.e1
• Publication Date: 2014-02-14
• Subjects: Depression -- Dementia -- Population‐based -- Epidemiology; Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1016/j.jalz.2013.10.006
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: Background: Whether depression is a long‐term risk factor for dementia or represents a dementia prodrome is unclear. Therefore, we examined the relationship between depressive symptoms and dementia during short and long follow‐up in a population‐based cohort. Methods: In the Rotterdam Study, 4393 nondemented individuals were followed for incident dementia for 13.7 years by continuous monitoring. Cox proportional hazards models for different time intervals were used to estimate the risk of incident dementia. Results: Five‐hundred eighty‐two participants developed dementia during 13.7 years. Persons with depressive symptoms had an 8% increased risk of dementia compared with those without depressive symptoms during the overall follow‐up. The risk was highest in the short and intermediate follow‐up, particularly in men. We did not find an association in the follow‐up period beyond 10 years. Conclusion: Our results suggest that late‐life depressive symptoms are part of a dementia prodrome rather than an independent risk factor of dementia.