A retrospective cohort study of preoperative lipid indices and their impact on new‐onset diabetes after liver transplantation. Issue 5 (24th January 2020)

• Record Type: Journal Article
• Authors: Liang, Jing; Yi, Xilu; Xue, Mengjuan; Chen, Xianying; Huang, Xiaowu; Sun, Qiman; Wang, Ting; Zhao, Chenhe; Yang, Yinqiu; Gao, Jian; Zhou, Jian; Fan, Jia; Yu, Mingxiang
• Is Part Of: Journal of clinical laboratory analysis. Volume 34:Issue 5(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-01-24
• Subjects: hypoglycemia -- liver transplantation -- new‐onset diabetes after transplantation -- preoperative lipid index -- triglycerides; Diagnosis, Laboratory -- Periodicals; Medical laboratory technology -- Periodicals; 616
• DOI: 10.1002/jcla.23192
• Languages: English
• ISSNs: 0887-8013

Abstract

Abstract: Background: The correlation between preoperative lipid profiles and new‐onset diabetes after transplantation (NODAT) remains relatively unexplored in liver transplant recipients (LTRs). Thus, we aimed to investigate the preoperative lipid profiles in Chinese LTRs and evaluate the different influences of preoperative total cholesterol, total triglycerides (TG), high‐density lipoprotein cholesterol, and low‐density lipoprotein cholesterol on the development of NODAT in both sexes. Methods: A total of 767 Chinese LTRs from Zhongshan Hospital were retrospectively evaluated. NODAT was defined according to the American Diabetes Association guidelines; the relationship between each preoperative lipid index and NODAT development was analyzed separately in men and women. Results: Pretransplant hypotriglyceridemia was observed in 35.72% of the total LTRs. In men, only the preoperative TG level was significantly associated with incident NODAT after adjusting for potential confounders (hazard ratio 1.37, 95% confidence interval 1.13‐1.66, P = .001). There was a nonlinear relationship between the preoperative TG level and NODAT risk. The risk of NODAT significantly increased with preoperative a TG level above 0.54 mmol/L (log‐likelihood ratio test, P = .043). In women, no significant association was observed. Conclusion: Among male LTRs, a higher preoperative TG level, even at a low level within the normal range, was significantly and nonlinearly associated with an increased risk of NODAT.