Population genetic data from 23 autosomal STR loci of Huaxia Platinum system in the Jining Han population. Issue 4 (29th January 2020)

• Record Type: Journal Article
• Authors: Dang, Zhen; Liu, Qi; Zhang, Guoan; Li, Shuyue; Wang, Dan; Pang, Qianqian; Yang, Da; Li, Changzheng; Cui, Wen; Wang, Yequan
• Is Part Of: Molecular genetics & genomic medicine. Volume 8:Issue 4(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-01-29
• Subjects: Eastern China -- genetic distance -- genetic polymorphism -- Jining Han -- short tandem repeat; Medical genetics -- Periodicals; Genomics -- Periodicals; 616.042
• DOI: 10.1002/mgg3.1142
• Languages: English
• ISSNs: 2324-9269

Abstract

Abstract: Background: Genetic polymorphisms at 23 short tandem repeat (STR) loci were investigated in 1, 215 Jining Han individuals from Jining city, Shandong province, eastern China. Methods: We used population genetic data of 23 autosomal STR loci included in the Huaxia Platinum system to evaluate 1, 215 unrelated Chinese Han individuals in the Jining Han population. Allele frequencies and forensic parameters of the STR loci were determined and genetic relationships among the Jining Han and other Chinese populations were evaluated. Results: In total, we observed 321 alleles, with frequencies ranging from 0.00041 to 0.52222. The combined discrimination power and probability of excluding paternity were 0.99999999999999999999999999919 and 0.99999999962, respectively. No deviations from HWE were observed at any loci. Population comparisons showed that the Xinjiang groups (Uyghur and Kazakh) and the Mongolian and Tibetan groups were isolated, while the Jining Han population clustered together with other populations, except the Guizhou Han population. Conclusion: This study demonstrated that 23 autosomal STR loci included in the Huaxia Platinum system are highly polymorphic and suitable for personal forensic identification and paternity testing in this population. Abstract : Genetic polymorphism at 23 short tandem repeat (STR) loci was investigated in 1, 215 Jining Han individuals from Jining city, Shandong province, eastern China. Allele frequencies and forensic parameters of the STR loci were determined and genetic relationships among the Jining Han and other Chinese populations were evaluated. The combined discrimination power and probability of excluding paternity were 0.99999999999999999999999999919 and 0.99999999962, respectively, demonstrating that these STRs are highly polymorphic and suitable for personal forensic identification and paternity testing in this population.