Partial Seeding Policy for Controlling the Crystal Quality in Batch Cooling Crystallization. Issue 6 (7th April 2020)

• Record Type: Journal Article
• Authors: Unno, Joi; Hirasawa, Izumi
• Other Names: Flood Adrian guestEditor.
• Is Part Of: Chemical engineering & technology. Volume 43:Issue 6(2020)
• Page Start: 1065
• Page End: 1071
• Publication Date: 2020-04-07
• Subjects: Crystallization -- Particle size -- Process control -- Seed crystals -- Simulation; Chemical engineering -- Periodicals; Chemical processes -- Periodicals; 660.05
• DOI: 10.1002/ceat.201900618
• Languages: English
• ISSNs: 0930-7516

Abstract

Abstract: Partial seeding, in which the nuclei originating from seed crystals grow to yield the product crystals, was simulated and optimized for controlling the batch cooling crystallization process of L ‐arginine. The product quality was evaluated by the coefficient of variation ( CV ) of the crystal size distribution. First, the optimum seed amount for partial seeding was estimated by simulation. Then, the simulated values of the optimum seed amount and the resulting local minimum CV were correlated with the seed crystal size and the cooling rate. The correlation can be utilized for estimating the seed amount in the case that the seed crystals are added in a slurry. Finally, these simulated values were compared to the measured ones. Consequently, the optimum seed amount was suggested to be reasonably predicted. Abstract : Partial seeding, in which the nuclei originating from seed crystals grow to yield the product crystals, was simulated and optimized for the crystallization of L ‐arginine. The optimum seed loading amount and the resulting product quality were correlated with the seed crystal size and the cooling rate. The simulated values were compared to the measured ones.