The biological mechanisms of butanol tolerance and the application of solvent‐tolerant bacteria for environmental protection. Issue 5 (27th November 2019)

• Record Type: Journal Article
• Authors: Gao, Yue; Zhang, Miao‐miao; Guo, Xiao‐peng; Li, Wen‐jian; Lu, Dong
• Is Part Of: Journal of chemical technology & biotechnology. Volume 95:Issue 5(2020)
• Page Start: 1290
• Page End: 1297
• Publication Date: 2019-11-27
• Subjects: butanol toxicity -- solvent stress -- solvent‐tolerant bacteria -- tolerance mechanisms -- applications; Biotechnology -- Periodicals; Chemistry, Technical -- Periodicals; Chemical engineering -- Periodicals; Industries -- Environmental aspects -- Periodicals; 660
• DOI: 10.1002/jctb.6255
• Languages: English
• ISSNs: 0268-2575

Abstract

Abstract: Toxicity caused by the accumulation of butanol in fermentation media is an important factor limiting the concentration of butanol. There is currently no systematic research in place investigating the butanol tolerance mechanism of bacteria such as Clostridium acetobutylicum, which adapts to butanol stress and regulates its growth and metabolism. Here, research results related to the butanol tolerance of C. acetobutylicum are reviewed to understand the molecular basis of changes in butanol‐tolerant strains. Organic solvent‐tolerant bacteria play an important role in the fields of biofuel production, enzyme preparation and bioremediation. An analysis of limitations of the application of organic solvent‐tolerant bacteria has revealed that future research should focus on combining the microbial tolerance phenotype with specific utilization to achieve an optimal balance between organic solvent tolerance and production. This review serves as a reference for the improvement and engineering of strains that tolerate organic solvents. © 2019 Society of Chemical Industry