Sex differences in functional and molecular neuroimaging biomarkers of Alzheimer's disease in cognitively normal older adults with subjective memory complaints. Issue 9 (6th July 2018)

• Record Type: Journal Article
• Authors: Cavedo, Enrica; Chiesa, Patrizia A.; Houot, Marion; Ferretti, Maria Teresa; Grothe, Michel J.; Teipel, Stefan J.; Lista, Simone; Habert, Marie‐Odile; Potier, Marie‐Claude; Dubois, Bruno; Hampel, Harald
• Is Part Of: Alzheimer's & dementia. Volume 14:Issue 9(2018)
• Page Start: 1204
• Page End: 1215
• Publication Date: 2018-07-06
• Subjects: Alzheimer's disease -- Sex -- Amyloid -- Cortical thickness -- FDG‐PET -- Hippocampus -- Basal forebrain -- Metabolism -- APOE -- Aging -- Cognitively intact older individuals; Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1016/j.jalz.2018.05.014
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: Introduction: Observational multimodal neuroimaging studies indicate sex differences in Alzheimer's disease pathophysiological markers. Methods: Positron emission tomography brain amyloid load, neurodegeneration (hippocampus and basal forebrain volumes adjusted to total intracranial volume, cortical thickness, and 2‐deoxy‐2‐[fluorine‐18]fluoro‐D‐glucose–positron emission tomography metabolism), and brain resting‐state functional connectivity were analyzed in 318 cognitively intact older adults from the INSIGHT‐preAD cohort (female n = 201, male n = 117). A linear mixed‐effects model was performed to investigate sex effects and sex∗apolipoprotein E genotype interaction on each marker as well as sex∗amyloid group interaction for non‐amyloid markers. Results: Men compared with women showed higher anterior cingulate cortex amyloid load ( P = .009), glucose hypometabolism in the precuneus ( P = .027), posterior cingulate ( P < .001) and inferior parietal ( P = .043) cortices, and lower resting‐state functional connectivity in the default mode network ( P = .024). No brain volumetric markers showed differences between men and women. Sex∗apolipoprotein E genotype and sex∗amyloid status interactions were not significant. Discussion: Our findings suggest that cognitively intact older men compared with women have higher resilience to pathophysiological processes of Alzheimer's disease.