Common, intermediate and well‐documented HLA alleles in world populations: CIWD version 3.0.0. (31st January 2020)

• Record Type: Journal Article
• Authors: Hurley, Carolyn K.; Kempenich, Jane; Wadsworth, Kim; Sauter, Jürgen; Hofmann, Jan A.; Schefzyk, Daniel; Schmidt, Alexander H.; Galarza, Pablo; Cardozo, Maria B. R.; Dudkiewicz, Malgorzata; Houdova, Lucie; Jindra, Pavel; Sorensen, Betina S.; Jagannathan, Latha; Mathur, Ankit; Linjama, Tiina; Torosian, Tigran; Freudenberger, Rafi; Manolis, Anastasios; Mavrommatis, John; Cereb, Nezih; Manor, Sigal; Shriki, Nira; Sacchi, Nicoletta; Ameen, Reem; Fisher, Raewyn; Dunckley, Heather; Andersen, Irene; Alaskar, Ahmed; Alzahrani, Mohsen; Hajeer, Ali; Jawdat, Dunia; Nicoloso, Grazia; Kupatawintu, Pawinee; Cho, Louise; Kaur, Ashminder; Bengtsson, Mats; Dehn, Jason;
• Is Part Of: HLA. Volume 95:Number 6(2020)
• Page Start: 516
• Page End: 531
• Publication Date: 2020-01-31
• Subjects: alleles -- ethnic groups -- gene frequency -- HLA; Immunogenetics -- Periodicals; Antigens -- Periodicals; HLA histocompatibility antigens -- Periodicals; 571.9645
• DOI: 10.1111/tan.13811
• Languages: English
• ISSNs: 2059-2302

Abstract

Abstract : A catalog of common, intermediate and well‐documented (CIWD) HLA‐A, ‐B, ‐C, ‐DRB1, ‐DRB3, ‐DRB4, ‐DRB5, ‐DQB1 and ‐DPB1 alleles has been compiled from over 8 million individuals using data from 20 unrelated hematopoietic stem cell volunteer donor registries. Individuals are divided into seven geographic/ancestral/ethnic groups and data are summarized for each group and for the total population. P (two‐field) and G group assignments are divided into one of four frequency categories: common (≥1 in 10 000), intermediate (≥1 in 100 000), well‐documented (≥5 occurrences) or not‐CIWD. Overall 26% of alleles in IPD‐IMGT/HLA version 3.31.0 at P group resolution fall into the three CIWD categories. The two‐field catalog includes 18% (n = 545) common, 17% (n = 513) intermediate, and 65% (n = 1997) well‐documented alleles. Full‐field allele frequency data are provided but are limited in value by the variations in resolution used by the registries. A recommended CIWD list is based on the most frequent category in the total or any of the seven geographic/ancestral/ethnic groups. Data are also provided so users can compile a catalog specific to the population groups that they serve. Comparisons are made to three previous CWD reports representing more limited population groups. This catalog, CIWD version 3.0.0, is a step closer to the collection of global HLA frequencies and to a clearer view of HLA diversity in the human population as a whole.