Corpora amylacea in benign prostatic acini are associated with concurrent, predominantly low‐grade cancer. Issue 9 (9th April 2020)

• Record Type: Journal Article
• Authors: Palangmonthip, Watchareepohn; Wu, Ruizhe; Tarima, Sergey; Bobholz, Samuel A.; LaViolette, Peter S.; Gallan, Alexander J.; Iczkowski, Kenneth A.
• Is Part Of: Prostate. Volume 80:Issue 9(2020)
• Page Start: 687
• Page End: 697
• Publication Date: 2020-04-09
• Subjects: corpora amylacea -- inflammation -- peripheral zone -- prediction of cancer -- prostate cancer -- transition zone; Prostate -- Diseases -- Periodicals; 616
• DOI: 10.1002/pros.23980
• Languages: English
• ISSNs: 0270-4137

Abstract

Abstract: Background: Corpora amylacea (CAM), in benign prostatic acini, contain acute‐phase proteins. Do CAM coincide with carcinoma? Methods: Within 270 biopsies, 83 prostatectomies, and 33 transurethral resections (TURs), CAM absence was designated CAM 0; corpora in less than 5% of benign acini: CAM 1; in 5% to 25%: CAM 2; in more than 25%: CAM 3. CAM were compared against carcinoma presence, clinicopathologic findings, and grade groups (GG) 1 to 2 vs 3 to 5. The frequency of CAM according to anatomic zone was counted. A pilot study was conducted using paired initial benign and repeat biopsies (33 benign, 24 carcinoma). Results: A total of 68.9% of biopsies, 96.4% of prostatectomies, and 66.7% of TURs disclosed CAM. CAM ≥1 was common at an older age ( P = .019). In biopsies, 204 cases (75%) had carcinoma; and CAM of 2 to 3 (compared to 0‐1) were recorded in 25.0% of carcinomas but only 7.4% of benign biopsies ( P = .005; odds ratio [OR] = 5.1). CAM correlated with high percent Gleason pattern 3, low GG ( P = .035), and chronic inflammation (CI). CI correlated inversely with carcinoma ( P = .003). CAM disclosed no association with race, body mass index, serum prostate specific antigen (PSA), acute inflammation (in biopsies), atrophy, or carcinoma volume. With CAM 1, the odds of GG 3 to 5 carcinoma, by comparison to CAM 0, decreased more than 2× (OR = 0.48; P = .032), with CAM 2, more than 3× (OR = 0.33; P = .005), and with CAM 3, almost 3× (OR = 0.39, P = .086). For men aged less than 65, carcinoma predictive model was: Score = (2 × age) + (5 × PSA) − (20 × degree of CAM); using our data, area under the ROC curve was 78.17%. When the transition zone was involved by cancer, it showed more CAM than in cases where it was uninvolved ( P = .012); otherwise zonal distributions were similar. In the pilot study, CAM ≥1 predicted carcinoma on repeat biopsy ( P < .05; OR = 8), as did CAM 2 to 3 ( P < .0001; OR = 30). CI was not significant, and CAM retained significance after adjusting for CI. Conclusion: CAM correlate with carcinoma. Whether abundant CAM in benign biopsies adds value amidst high clinical suspicion, warrants further study.