Asymmetric Catalytic 1, 2‐Dihydrophosphination of Secondary 1, 2‐Diphosphines – Direct Access to Free P*‐ and P*, C*‐Diphosphines. Issue 12 (23rd April 2020)

• Record Type: Journal Article
• Authors: Teo, Ronald Hong Xiang; Chen, Houguang Jeremy; Li, Yongxin; Pullarkat, Sumod A.; Leung, Pak‐Hing
• Is Part Of: Advanced synthesis & catalysis. Volume 362:Issue 12(2020)
• Page Start: 2373
• Page End: 2378
• Publication Date: 2020-04-23
• Subjects: Asymmetric Catalysis -- Chirality -- Hydrophosphination -- Palladium -- Phosphines; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202000131
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A 1, 2‐dihydrophosphination of bis(phenylphosphino)ethane with a wide range of activated olefins was achieved in a catalytic manner with enantiomeric and diastereomeric excess of up to >99% and 44% respectively. The protocol can be extended to selected substrates leading to free P ‐ and C ‐chiral 1, 2‐diphosphines. The synthesized ligands can also undergo direct complexation onto palladium affording complexes with complete retention of stereo‐integrity. Abstract :