Direct Arylations via C–H Bond Functionalization of 1, 2, 3‐Triazoles by a Reusable Pd/C Catalyst Under Solvent‐Free Conditions. Issue 22 (28th October 2019)

• Record Type: Journal Article
• Authors: Punzi, Angela; Zappimbulso, Nicola; Farinola, Gianluca M.
• Is Part Of: European journal of organic chemistry. Issue 22(2020)
• Page Start: 3229
• Page End: 3234
• Publication Date: 2019-10-28
• Subjects: C–H activation -- Solvent‐free reactions -- Heterogeneous catalysis -- 1, 2, 3‐Triazoles -- Nitrogen‐based heterocycles; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201901305
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : Fully substituted triazoles are synthesized by a sustainable direct arylation reaction performed under solvent‐free conditions and in the presence of a recyclable Pd/C heterogeneous catalyst. Exclusion of air as well as anhydrous conditions are not required, enabling a convenient synthesis of 1, 4, 5‐trisubstituted 1, 2, 3‐triazoles and 1, 2, 3‐triazole‐fused isoindolines starting from 1, 4‐disubstituted 1, 2, 3‐triazoles, easily prepared via click chemistry, and functionalized aryl iodides. Abstract : 1, 4, 5‐Trisubstituted 1, 2, 3‐triazoles and 1, 2, 3‐triazole‐fused isoindolines are synthesized by a sustainable Pd‐catalyzed direct arylation reaction performed under solvent‐free conditions and in the presence of a recyclable heterogeneous catalyst.