Ruthenium‐Catalyzed meta‐CAr–H Bond Difluoroalkylation of 2‐Phenoxypyridines. Issue 13 (17th March 2020)

• Record Type: Journal Article
• Authors: Jia, Chunqi; Wang, Shichong; Lv, Xulu; Li, Gang; Zhong, Lei; Zou, Lei; Cui, Xiuling
• Is Part Of: European journal of organic chemistry. Issue 13(2020)
• Page Start: 1992
• Page End: 1995
• Publication Date: 2020-03-17
• Subjects: Ruthenium -- C–H activation -- meta‐CAr–H -- Difluoroalkylation -- Phenoxypyridine; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201901883
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : A ruthenium‐catalyzed meta ‐selective CAr –H bond difluoroalkylation of 2‐phenoxypyridine using 2‐bromo‐2, 2‐difluoroacetate has been developed. Mechanistic studies indicated that this difluoroalkylation might involve a radical process. Furthermore, a new method is reported for the synthesis of 2‐( meta ‐difluoroalkylphenoxy)pyridine derivatives, which are present in many pharmaceuticals and other functional compounds. Abstract : A ruthenium‐catalyzed meta ‐selective CAr –H bond difluoroalkylation of 2‐phenoxypyridine using 2‐bromo‐2, 2‐difluoroacetate has been developed, which provide a new method to synthesize 2‐( meta ‐difluoroalkylphenoxy)pyridine derivatives, which are present in many pharmaceuticals and other functional compounds.