Biosynthetic Interrelationships within Polycyclic Cembranoids Isolated from Corals: Conjecture, Biomimetic Synthesis and Reality. Issue 16 (29th November 2019)

• Record Type: Journal Article
• Authors: Palframan, Matthew J.; Pattenden, Gerald
• Other Names: Aggarwal Varinder K. guestEditor.
• Is Part Of: European journal of organic chemistry. Issue 16(2020)
• Page Start: 2330
• Page End: 2349
• Publication Date: 2019-11-29
• Subjects: Biomimetic synthesis -- Cycloaddition -- Natural products -- Macrocycles -- Furanobutenolide‐cembranoids; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201901438
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : Macrocyclic furanobutenolide‐based cembranoids are precursors to a wide variety of complex ring‐fused diterpene structures in corals, implicating a wide variety of oxidation and photochemical processes, cyclisation and transannulation reactions, and skeletal rearrangements from a variety of reactive intermediates and pericyclic processes. This article gives an up to date personal perspective on the speculations that underpin these interesting biosynthetic interrelationships and summarises biomimetic synthesis and interconversions that would seem to vindicate some of these speculations. Abstract : Macrocyclic furanobutenolide‐based cembranoids are precursors to a wide variety of complex ring‐fused diterpene structures in corals, implicating a wide variety of oxidation and transannular cyclisations. This article gives a personal perspective on the speculations that underpin these biosynthetic interrelationships and summarises biomimetic synthesis studies designed to probe these speculations.