Cobalt‐Catalyzed Direct Arylation of Imidazo[1, 2‐a]pyridine with Aryl Iodides. Issue 12 (13th March 2020)

• Record Type: Journal Article
• Authors: Babar, Dattatraya A.; Rode, Haridas B.
• Is Part Of: European journal of organic chemistry. Issue 12(2020)
• Page Start: 1823
• Page End: 1827
• Publication Date: 2020-03-13
• Subjects: Imidazo[1, 2‐a]pyridine -- C–H activation -- Privileged scaffolds -- Arylation -- Heterocycles -- Transition metals; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.202000006
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : The Co(II)Cl2 · 6H2 O catalyzed C–H activation/direct arylation of imidazo[1, 2‐ a ]pyridine with aryl/heteroaryl iodide is reported. The cost effective, ligand and additive free protocol using KOAc successfully afforded 3‐arylimidazo[1, 2‐ a ]pyridines in good yields. Imidazo[1, 2‐ a ]pyridines with electron withdrawing and electron donating substituents with various aryl iodides are well tolerated. The reaction is performed in a Screw‐top V‐Vial® to expedite the synthesis. The antibacterial 3‐naphthyl imidazo[1, 2‐ a ]pyridine is smoothly prepared using this protocol. Abstract : A practical protocol for the C‐3 arylation of imidazo[1, 2‐ a ]pyridines with aryl/heteroaryl iodides using Co(II)Cl2 · 6H2 O is reported. The reaction can be performed in a Screw‐top V‐Vial® to expedite the synthesis.