Engineering of Laccase CueO for Improved Electron Transfer in Bioelectrocatalysis by Semi‐Rational Design. Issue 22 (16th April 2020)

• Record Type: Journal Article
• Authors: Zhang, Lingling; Cui, Haiyang; Dhoke, Gaurao V.; Zou, Zhi; Sauer, Daniel F.; Davari, Mehdi D.; Schwaneberg, Ulrich
• Is Part Of: Chemistry. Volume 26:Issue 22(2020)
• Page Start: 4884
• Page End: 4884
• Publication Date: 2020-04-16
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.202001027
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: Invited for the cover of this issue is the group of Ulrich Schwaneberg at the Institute of Biotechnology, RWTH‐Aachen University and DWI Lebniz Institute of Interactive Materials. The picture calls for special attention to be paid to the extra Cu binding site of Copper efflux Oxidase (CueO), due to its predominant function in tuning the electrocatalytic kinetics towards oxygen reduction. Read the full text of the article at 10.1002/chem.201905598 . Abstract : " The effect of the fifth Cu binding and coordination on the electrocatalysis kinetics towards oxygen reduction is revealed. Interestingly, substitutions work at all four coordinated positions for kinetics manipulation. The reason might be the increase in localized structural stability of the fifth Cu binding site and the decrease of electron transfer distance between the fifth Cu and the T1 Cu, according to the molecular dynamic simulation ." Read more about the story behind the cover in the Cover Profile and about the research itself on page 4974 ff. (DOI: 10.1002/chem.201905598 ).