Dioscorea esculenta‐induced increase in muscle sex steroid hormones is associated with enhanced insulin sensitivity in a type 2 diabetes rat model. Issue 2 (8th November 2016)
- Record Type:
- Journal Article
- Title:
- Dioscorea esculenta‐induced increase in muscle sex steroid hormones is associated with enhanced insulin sensitivity in a type 2 diabetes rat model. Issue 2 (8th November 2016)
- Main Title:
- Dioscorea esculenta‐induced increase in muscle sex steroid hormones is associated with enhanced insulin sensitivity in a type 2 diabetes rat model
- Authors:
- Sato, Koji
Fujita, Satoshi
Iemitsu, Motoyuki - Abstract:
- ABSTRACT: The effects of chronic Dioscorea esculenta administration and exercise training on muscle sex steroid hormone levels and insulin resistance in type 2 diabetes rats was assessed. Twenty‐week‐old male Otsuka Long Evans Tokushima Fatty (OLETF) rats were assigned randomly to the control, D. esculenta treatment, D. esculenta with 5α‐reductase inhibitor treatment, or the exercise training groups (running at 25 m/min for 1 h, 5 d/wk; n = 10 each group). Eight weeks of D. esculenta treatment or exercise training significantly attenuated the increase in plasma insulin and fasting glucose levels. Plasma and muscle concentrations of dehydroepiandrosterone and 5adihydrotestosterone (DHT) and the expression of 5α‐reductase increased significantly in the D. esculenta ‐treated and exercise training groups, and both treatments led to the upregulation of glucose transporter‐4 translocation with concomitant increases in PKB and PKC‐ζ/λ phosphorylation. Furthermore, the glucose metabolic clearance rate, which represents insulin sensitivity, increased significantly in both the D. esculenta ‐treated and exercise training groups. These effects were suppressed by administration of the DHT synthetic inhibitor. Together, these findings suggest that the D. esculenta ‐induced increase in muscle sex steroid hormone levels helps decrease insulin resistance in type 2 diabetes.—Sato, K., Fujita, S., Iemitsu, M. Dioscorea esculenta ‐induced increase in muscle sex steroid hormones is associatedABSTRACT: The effects of chronic Dioscorea esculenta administration and exercise training on muscle sex steroid hormone levels and insulin resistance in type 2 diabetes rats was assessed. Twenty‐week‐old male Otsuka Long Evans Tokushima Fatty (OLETF) rats were assigned randomly to the control, D. esculenta treatment, D. esculenta with 5α‐reductase inhibitor treatment, or the exercise training groups (running at 25 m/min for 1 h, 5 d/wk; n = 10 each group). Eight weeks of D. esculenta treatment or exercise training significantly attenuated the increase in plasma insulin and fasting glucose levels. Plasma and muscle concentrations of dehydroepiandrosterone and 5adihydrotestosterone (DHT) and the expression of 5α‐reductase increased significantly in the D. esculenta ‐treated and exercise training groups, and both treatments led to the upregulation of glucose transporter‐4 translocation with concomitant increases in PKB and PKC‐ζ/λ phosphorylation. Furthermore, the glucose metabolic clearance rate, which represents insulin sensitivity, increased significantly in both the D. esculenta ‐treated and exercise training groups. These effects were suppressed by administration of the DHT synthetic inhibitor. Together, these findings suggest that the D. esculenta ‐induced increase in muscle sex steroid hormone levels helps decrease insulin resistance in type 2 diabetes.—Sato, K., Fujita, S., Iemitsu, M. Dioscorea esculenta ‐induced increase in muscle sex steroid hormones is associated with enhanced insulin sensitivity in a type 2 diabetes rat model. FASEB J. 31, 793–801 (2017). http://www.fasebj.org … (more)
- Is Part Of:
- FASEB journal. Volume 31:Issue 2(2017)
- Journal:
- FASEB journal
- Issue:
- Volume 31:Issue 2(2017)
- Issue Display:
- Volume 31, Issue 2 (2017)
- Year:
- 2017
- Volume:
- 31
- Issue:
- 2
- Issue Sort Value:
- 2017-0031-0002-0000
- Page Start:
- 793
- Page End:
- 801
- Publication Date:
- 2016-11-08
- Subjects:
- diosgenin -- insulin resistance -- exercise -- DHT
Biology -- Periodicals
Biology, Experimental -- Periodicals
570 - Journal URLs:
- http://onlinelibrary.wiley.com/ ↗
- DOI:
- 10.1096/fj.201600874R ↗
- Languages:
- English
- ISSNs:
- 0892-6638
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 13234.xml