Men and women differ in their diurnal expression of monocyte peroxisome proliferator‐activated receptor‐α in the fed but not in the fasted state. Issue 7 (30th March 2015)
- Record Type:
- Journal Article
- Title:
- Men and women differ in their diurnal expression of monocyte peroxisome proliferator‐activated receptor‐α in the fed but not in the fasted state. Issue 7 (30th March 2015)
- Main Title:
- Men and women differ in their diurnal expression of monocyte peroxisome proliferator‐activated receptor‐α in the fed but not in the fasted state
- Authors:
- Wege, Nicole
Schutkowski, Alexandra
Boenn, Markus
Bialek, Joanna
Schlitt, Axel
Noack, Frank
Grosse, Ivo
Stangl, Gabriele I. - Abstract:
- ABSTRACT: Peroxisome proliferator‐activated receptor‐α (PPARα) plays a pivotal role in regulating metabolic response to fasting and is an inhibitor of inflammatory pathways in immune cells. It represents a therapeutic target for treatment of several diseases, mainly hyperlipidemia. To shed light on PPARα expression changes in response to fasting, young healthy male and female volunteers were fed or fasted for 24 hours. Monocytes were analyzed every 2 hours to compile both profiles of mRNA and protein expression of PPARα and its interactive partner, the circadian pacemaker brain and muscle aryl hydrocarbon receptor nuclear translocator like‐1 (BMAL1). We found that women change their diurnal expression profiles of PPARα and BMAL1 when switching from the fed to the fasted state, whereas men do not. Interestingly, the PPARα and BMAL1 profiles of men and women in the fed state are different, whereas the profiles in the fasted state are virtually identical. The finding of diametrically opposite responses of male and female PPARα expression in the fed state might have practical implication in human medicine as PPARα activators like fibrates are used for the therapy of chronic lymphocytic leukemia, microvascular complications in diabetes, and kidney diseases.—Wege, N., Schutkowski, A., Boenn, M., Bialek, J., Schlitt, A., Noack, F., Grosse, I., Stangl, G. I. Men and women differ in their diurnal expression of monocyte peroxisome proliferator‐activated receptor‐a in the fed but notABSTRACT: Peroxisome proliferator‐activated receptor‐α (PPARα) plays a pivotal role in regulating metabolic response to fasting and is an inhibitor of inflammatory pathways in immune cells. It represents a therapeutic target for treatment of several diseases, mainly hyperlipidemia. To shed light on PPARα expression changes in response to fasting, young healthy male and female volunteers were fed or fasted for 24 hours. Monocytes were analyzed every 2 hours to compile both profiles of mRNA and protein expression of PPARα and its interactive partner, the circadian pacemaker brain and muscle aryl hydrocarbon receptor nuclear translocator like‐1 (BMAL1). We found that women change their diurnal expression profiles of PPARα and BMAL1 when switching from the fed to the fasted state, whereas men do not. Interestingly, the PPARα and BMAL1 profiles of men and women in the fed state are different, whereas the profiles in the fasted state are virtually identical. The finding of diametrically opposite responses of male and female PPARα expression in the fed state might have practical implication in human medicine as PPARα activators like fibrates are used for the therapy of chronic lymphocytic leukemia, microvascular complications in diabetes, and kidney diseases.—Wege, N., Schutkowski, A., Boenn, M., Bialek, J., Schlitt, A., Noack, F., Grosse, I., Stangl, G. I. Men and women differ in their diurnal expression of monocyte peroxisome proliferator‐activated receptor‐a in the fed but not in the fasted state. FASEB J . 29, 2905‐2911 (2015). www.fasebj.org … (more)
- Is Part Of:
- FASEB journal. Volume 29:Issue 7(2015)
- Journal:
- FASEB journal
- Issue:
- Volume 29:Issue 7(2015)
- Issue Display:
- Volume 29, Issue 7 (2015)
- Year:
- 2015
- Volume:
- 29
- Issue:
- 7
- Issue Sort Value:
- 2015-0029-0007-0000
- Page Start:
- 2905
- Page End:
- 2911
- Publication Date:
- 2015-03-30
- Subjects:
- caloric intake -- nuclear receptor -- circadian pacemaker
Biology -- Periodicals
Biology, Experimental -- Periodicals
570 - Journal URLs:
- http://onlinelibrary.wiley.com/ ↗
- DOI:
- 10.1096/fj.14-267575 ↗
- Languages:
- English
- ISSNs:
- 0892-6638
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 13234.xml