Characteristics and influence of Mycoplasma/Ureaplasma cultures in amniotic fluid on perinatal outcomes. Issue 3 (27th December 2019)

• Record Type: Journal Article
• Authors: Takakura, Sho; Kodama, Yuki; Yamashita, Rie; Kino, Emi; Kawano, Noriko; Tomimori, Kayo; Maki, Yohei; Doi, Koutarou; Kaneko, Masatoki; Sameshima, Hiroshi
• Is Part Of: Journal of obstetrics and gynaecology research. Volume 46:Issue 3(2020)
• Page Start: 389
• Page End: 395
• Publication Date: 2019-12-27
• Subjects: amniocentesis -- bronchopulmonary dysplasia -- intrauterine infection -- Mycoplasma hominis -- Ureaplasma urealyticum; Gynecology -- Periodicals; Obstetrics -- Periodicals; 618.1005
• DOI: 10.1111/jog.14183
• Languages: English
• ISSNs: 1341-8076

Abstract

Abstract: Aim: To investigate the effects of Mycoplasma / Ureaplasma cultured in amniotic fluid on perinatal characteristics in preterm delivery between 22 and 33 weeks of gestation. Methods: The study was conducted in a tertiary perinatal center and involved 38 pregnant women who had undergone amniocentesis to evaluate intrauterine infection due to preterm labor or premature rupture of membranes. The subjects were divided into three groups based on the culture results: negative (Negative Group, n = 24), positive for Mycoplasma / Ureaplasma (M/U Group, n = 6), and positive for other pathogens (Other Pathogens Group, n = 8). One‐way analysis of variance was used to compare the three groups. Results: The incidence of histological chorioamnionitis and neonatal sepsis was significantly different among the three groups (the Negative Group and the Other Pathogens Group, P < 0.01; the M/U Group and the Other Pathogens Group, P = 0.03). In the M/U Group, no infants had sepsis, severe intraventricular hemorrhage, cystic periventricular leukomalacia, or poor neurological outcomes, but one infant developed bronchopulmonary dysplasia and needed home oxygen treatment. Although one died of gastrorrhexis, the remaining five patients had normal brain magnetic resonance imaging findings and developed normally. Conclusion: The presence of Mycoplasma / Ureaplasma isolated from amniotic fluid did not cause neonatal sepsis or poor prognosis. In some infants, there was no histological chorioamnionitis in the placenta. These pathogens thus seem to be less invasive than any other microbes with respect to perinatal outcomes.