TP and/or EP3 receptors mediate the vasoconstrictor and pressor responses of prostaglandin F2α in mice and/or humans. Issue 2 (2nd October 2018)

• Record Type: Journal Article
• Authors: Liu, Bin; Li, Jiarong; Yan, Hongfei; Tian, Dongping; Li, Hui; Zhang, Yingzhan; Guo, Tingting; Wu, Xiangzhong; Luo, Wenhong; Zhou, Yingbi
• Is Part Of: FASEB journal. Volume 33:Issue 2(2019)
• Page Start: 2451
• Page End: 2459
• Publication Date: 2018-10-02
• Subjects: prostanoid -- cyclooxygenase -- blood pressure; Biology -- Periodicals; Biology, Experimental -- Periodicals; 570
• DOI: 10.1096/fj.201801064RR
• Languages: English
• ISSNs: 0892-6638

Abstract

ABSTRACT: The vasoconstrictor and/or pressor effects of prostaglandin (PG)F2α participate in the development of vascular pathologies and limit the clinical use of the agent. This study aimed to determine the receptor types responsible for the vasoconstrictor activity of PGF2α and whether they mediate the pressor response evoked by the prostanoid under in vivo conditions. Experiments were performed on genetically altered mice and/or on vessels from these mice or humans. Here we show that deletion of the thromboxane‐prostanoid receptor (TP −/− ) abolished or drastically diminished the contraction to PGF2α in isolated mouse vessels (some of which were resistance arteries) and reduced the elevation in blood pressure evoked by the prostanoid under in vivo conditions. In accordance, TP antagonism abolished the contraction in small arteries of human omentum. Further deletion of E prostanoid receptor type 3 (EP3 −/− ) removed the PGF2α ‐evoked contraction that remained in some TP −/− arteries and added to the effect of TP −/− on the elevation in blood pressure evoked by the prostanoid under in vivo conditions. In contrast, the uterine contraction to PGF2α mediated via the F prostanoid receptor (FP) was unaltered in TP −/− /EP3 −/− mice. These results demonstrate that the non‐FP receptors TP and/or EP3 mediate the vasoconstrictor and pressor effects of PGF2α, which are still of concern under clinical conditions.—Liu, B., Li, J., Yan, H., Tian, D., Li, H., Zhang, Y., Guo, T., Wu, X., Luo, W., Zhou, Y. TP and/or EP3 receptors mediate the vasoconstrictor and pressor responses of prostaglandin F2α in mice and/or humans. FASEB J. 33, 2451–2459 (2019). www.fasebj.org