Vitamin D/VDR signaling suppresses microRNA‐802‐induced apoptosis of keratinocytes in oral lichen planus. Issue 1 (3rd August 2018)

• Record Type: Journal Article
• Authors: Zhao, Bin; Xu, Na; Li, Ran; Yu, Feiyan; Zhang, Fang; Yang, Fang; Ge, Xuejun; Li, Yan Chun; Du, Jie
• Is Part Of: FASEB journal. Volume 33:Issue 1(2019)
• Page Start: 1042
• Page End: 1050
• Publication Date: 2018-08-03
• Subjects: vitamin D receptor -- NF-κB -- Bcl2; Biology -- Periodicals; Biology, Experimental -- Periodicals; 570
• DOI: 10.1096/fj.201801020RRR
• Languages: English
• ISSNs: 0892-6638

Abstract

ABSTRACT: Vitamin D is known to play a protective role in inflammatory diseases. Although the suppressive effect of vitamin D/vitamin D receptor (VDR) signaling has been shown in the context of oral lichen planus (OLP), the molecular basis of its regulatory function remains poorly understood. Herein, we reported that miR‐802 over‐expression in OLP could aggravate apoptosis of oral keratinocytes by targeting B‐cell lymphoma 2 mRNA. In addition, vitamin D/VDR signaling was able to suppress miR‐802 expression in LPS‐treated or activated CD4 + T cell‐stimulated human oral keratinocytes by blocking NF‐κB pathways, thereby inhibiting OLP apoptosis. Consistent with the results in vitro, we showed that miR‐802 expression was enhanced in oral keratinocytes from VDR ‐/‐ mice, and an inverse correlation between VDR and miR‐802 was found in human biopsy specimens of OLP. Collectively, our data suggest that vitamin D/VDR signaling suppresses oral keratinocyte apoptosis by targeting miR‐802.—Zhao, B., Xu, N., Li, R., Yu, F., Zhang, F., Yang, F., Ge, X., Li, Y. C., Du, J. Vitamin D/VDR signaling suppresses microRNA‐802‐induced apoptosis of keratinocytes in oral lichen planus. FASEB J. 33, 1042–1050 (2019). www.fasebj.org