MiR‐205 suppresses tumor growth, invasion, and epithelial‐mesenchymal transition by targeting SEMA4C in hepatocellular carcinoma. Issue 11 (25th May 2018)

• Record Type: Journal Article
• Authors: Lu, Jiong; Lin, Yixin; Li, Fuyu; Ye, Hui; Zhou, Rongxing; Jin, Yanwen; Li, Bei; Xiong, Xianze; Cheng, Nansheng
• Is Part Of: FASEB journal. Volume 32:Issue 11(2018)
• Page Start: 6123
• Page End: 6134
• Publication Date: 2018-05-25
• Subjects: microRNA -- EMT -- SEMA4C -- HCC; Biology -- Periodicals; Biology, Experimental -- Periodicals; 570
• DOI: 10.1096/fj.201800113R
• Languages: English
• ISSNs: 0892-6638

Abstract

ABSTRACT: Growing evidence indicates that microRNAs are involved in tumorigenesis and progression of hepa tocellular carcinoma (HCC). However, the functional mechanisms of miR‐205 in HCC remain largely unknown. Here, we demonstrate that miR‐205 expression was significantly down‐regulated in HCC tissues and cell lines and was correlated with metastatic pathologic features and shorter disease‐free and overall survival. Overexpression of miR‐205 dramatically inhibited HCC cell proliferation, apoptosis, migration, invasion, epithelial‐mesenchymal transition (EMT) in vitro, and tumor growth in vivo. We subsequently identified semaphorin 4C (SEMA4C) as a novel target of miR‐205. Furthermore, high expression levels of SEMA4C were frequently found in HCC tissues and were associated with poor prognosis. Ectopic expression of SEMA4C restored the suppressive effect of overex pressed miR‐205 on migration, invasion, and EMT. Taken together, our findings provide new insight into the critical role of miR‐205 in regulating tumor growth, invasion, and EMT of HCC, suggesting miR‐205 may serve as a promising therapeutic target and novel prognostic indicator for patients with HCC.—Lu, J., Lin, Y., Li, F., Ye, H., Zhou, R., Jin, Y., Li, B., Xiong, X., Cheng, N. MiR‐205 suppresses tumor growth, invasion, and epithelialmesenchymal transition by targeting SEMA4C in hepatocellular carcinoma. FASEB J. 32, 6123–6134 (2018). www.fasebj.org