Physical fitness in community‐dwelling older adults is linked to dietary intake, gut microbiota, and metabolomic signatures. Issue 3 (22nd January 2020)

• Record Type: Journal Article
• Authors: Castro‐Mejía, Josué L.; Khakimov, Bekzod; Krych, Łukasz; Bülow, Jacob; Bechshøft, Rasmus L.; Højfeldt, Grith; Mertz, Kenneth H.; Garne, Eva Stahl; Schacht, Simon R.; Ahmad, Hajar F.; Kot, Witold; Hansen, Lars H.; Perez‐Cueto, Federico J. A.; Lind, Mads V.; Lassen, Aske J.; Tetens, Inge; Jensen, Tenna; Reitelseder, Søren; Jespersen, Astrid P.; Holm, Lars; Engelsen, Søren B.; Nielsen, Dennis S.
• Is Part Of: Aging cell. Volume 19:Issue 3(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-01-22
• Subjects: aging -- energy and dietary fiber intake -- gut microbiota -- host metabolome -- physical fitness -- proinsulin‐C‐peptide; Cells -- Aging -- Periodicals; 571.8783605
• DOI: 10.1111/acel.13105
• Languages: English
• ISSNs: 1474-9718

Abstract

Abstract: When humans age, changes in body composition arise along with lifestyle‐associated disorders influencing fitness and physical decline. Here we provide a comprehensive view of dietary intake, physical activity, gut microbiota (GM), and host metabolome in relation to physical fitness of 207 community‐dwelling subjects aged +65 years. Stratification on anthropometric/body composition/physical performance measurements (ABPm) variables identified two phenotypes (high/low‐fitness) clearly linked to dietary intake, physical activity, GM, and host metabolome patterns. Strikingly, despite a higher energy intake high‐fitness subjects were characterized by leaner bodies and lower fasting proinsulin‐C‐peptide/blood glucose levels in a mechanism likely driven by higher dietary fiber intake, physical activity and increased abundance of Bifidobacteriales and Clostridiales species in GM and associated metabolites (i.e., enterolactone). These factors explained 50.1% of the individual variation in physical fitness. We propose that targeting dietary strategies for modulation of GM and host metabolome interactions may allow establishing therapeutic approaches to delay and possibly revert comorbidities of aging. Abstract : Physical fitness among older subjects is characterized by variations in glycemic regulation in a mechanism likely driven by energy and dietary fiber intake, differential abundance of Bifidobacteriales and Clostridiales species in GM and their associated metabolites (i.e., enterolactone). Several signatures seen in frail older adults are already evident in nonfrail, pointing at the importance of early intervention strategies also in this age group.