Asymmetric Intramolecular Hydroalkoxylation of Unactivated Alkenes Catalyzed by Chiral N‐Triflyl Phosphoramide and TiCl4†. Issue 6 (10th April 2020)

• Record Type: Journal Article
• Authors: Zhao, Pengyuan; Cheng, Aolin; Wang, Xinxu; Ma, Jiguo; Zhao, Guoqing; Li, Yingkun; Zhang, Yi; Zhao, Baoguo
• Is Part Of: Chinese journal of chemistry. Volume 38:Issue 6(2020)
• Page Start: 565
• Page End: 569
• Publication Date: 2020-04-10
• Subjects: Asymmetric hydroalkoxylation -- Asymmetric catalysis -- Chiral super strong Brønsted acid -- Cyclization -- Chiral terahedrofuran; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/cjoc.201900544
• Languages: English
• ISSNs: 1001-604X

Abstract

Summary of main observation and conclusion: By using a combination of a chiral N ‐triflyl phosphoramide and TiCl4 as the catalyst, a new process for asymmetric intramolecular hydroalkoxylation of unactivated alkenes was developed, producing various chiral tetrahydrofuran derivatives in 51%—99% yields with 30%—71% ee's. Abstract : A combination of N ‐triflyl phosphoramide and TiCl4 challenges asymmetric hydroalkoxylation of unactivated alkenes.