Health utility and quality of life in pediatric liver transplant recipients. (26th April 2020)

• Record Type: Journal Article
• Authors: Bharij, Aashiv; Neighbors, Katie; Alonso, Estella M.; Mohammad, Saeed
• Is Part Of: Pediatric transplantation. Volume 24:Number 4(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-04-26
• Subjects: cost‐effectiveness -- economics -- health‐related quality of life -- standard gamble -- time trade‐off; Transplantation of organs, tissues, etc. in children -- Periodicals; 617.95408305
• DOI: 10.1111/petr.13720
• Languages: English
• ISSNs: 1397-3142

Abstract

Abstract: To measure HU and HRQOL in pediatric liver transplant (LT) recipients, a cross‐sectional study of patient‐parent dyads was conducted. Direct HU were assessed in 48 adolescents ≥12 years using SG and TTO techniques. Indirect HU were measured by Health Utility Index 2 and HUI3 for subjects ≥12 years and CHU9D for ≥7 years. Patients reported HRQOL using PedsQL™ GC and PedsQL™ TM. A total of 108 dyads participated (55.6% female; 73.2% Caucasian; 42.6% biliary atresia; 35.2% living donor; 37.0% Medicaid). Mean age at survey was 13.6 ± 3.5 years, and time from LT was 8.9 ± 4.9 years. 61.2% were on monotherapy, 25 (23.2%) had acute rejection within 3 years, and 15 (13.9%) had a biliary obstruction within 5 years. Mean indirect HU and HRQOL scores by child report were lower than norms ( P < .001). LRD recipients had higher PedsQL™ GC, PedsQL™ TM, and HUI3 scores ( P < .01). HU in pediatric LT recipients are lower than norms. Availability of HU scores for post‐transplant health states will enable measurement of quality‐adjusted life years for future comparative effectiveness studies.