Risk factors for incident dementia after stroke and transient ischemic attack. Issue 1 (5th March 2014)

• Record Type: Journal Article
• Authors: Yang, Jie; Wong, Adrian; Wang, Zhaolu; Liu, Wenyan; Au, Lisa; Xiong, Yunyun; Chu, Winnie W.C.; Leung, Eric Y.L.; Chen, Sirong; Lau, Christine; Chan, Anne Y.Y.; Lau, Alexander Y.L.; Fan, Florence; Ip, Vincent; Soo, Yannie; Leung, Thomas; Ho, Chi L.; Wong, Lawrence K.S.; Mok, Vincent C.T.
• Is Part Of: Alzheimer's & dementia. Volume 11:Issue 1(2015)
• Page Start: 16
• Page End: 23
• Publication Date: 2014-03-05
• Subjects: Poststroke dementia -- Vascular cognitive impairment -- Brain atrophy -- PiB‐PET -- Transient ischemic attack; Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1016/j.jalz.2014.01.003
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: Background: We hypothesized that chronic brain changes are important substrates for incident dementia after stroke and transient ischemic attack (TIA). Methods: We compared clinical and imaging features between patients with consecutive stroke/TIA with (n = 88) and without (n = 925) incident dementia at 3 to 6 months after a stroke/TIA. Pittsburg compound B (PiB) positron emission tomography was performed in 50 patients, including those with (n = 37) and without (n = 13) incident dementia. Results: Age, history of diabetes mellitus, severity of white matter changes (WMCs), and medial temporal lobe atrophy (MTLA) were associated with incident dementia. Alzheimer's disease (AD)–like PiB retention was found in 29.7% and 7.7% ( P = .032) of patients with and without incident dementia, respectively. Conclusions: Chronic brain changes including WMCs, MTLA, and AD pathology are associated with incident dementia after stroke/TIA. Interventions targeting these chronic brain changes may reduce burden of vascular cognitive impairment.