Age‐associated changes in chronic rhinosinusitis endotypes. Issue 5 (28th February 2020)

• Record Type: Journal Article
• Authors: Ryu, Gwanghui; Dhong, Hun‐Jong; Park, Minsu; Hwang, Na Young; Kim, Dong‐Kyu; Kim, Hyo Yeol; Chung, Seung‐Kyu; Rhee, Chae‐Seo; Cho, Seong‐Ho; Hong, Sang Duk; Kim, Dae Woo
• Is Part Of: Clinical & experimental allergy. Volume 50:Issue 5(2020)
• Page Start: 585
• Page End: 596
• Publication Date: 2020-02-28
• Subjects: age -- cytokine -- endotype -- rhinosinusitis; Allergy -- Periodicals; Immunology -- Periodicals; 616.97
• DOI: 10.1111/cea.13586
• Languages: English
• ISSNs: 0954-7894

Abstract

Abstract: Background: Immunologic function in innate and adaptive immunity changes with the ageing process. Thus, age‐related cytokine profiles in chronic rhinosinusitis (CRS) need to be investigated for precision medicine. Objective: The objective of this study was to characterize age‐related changes in immunologic profiles according to CRS subtypes. Methods: Subjects in control (n = 29), CRS without nasal polyps (CRSsNP, n = 86), and CRS with nasal polyps (eosinophilic NP: ENP, n = 81; non‐eosinophilic NP: NENP, n = 113) were enrolled in this study. Twenty markers for type 1/2/3 inflammation and other inflammatory processes were measured in homogenates of sinonasal tissues and statistically analysed. Results: In control tissues, type 2/3 and proinflammatory mediators showed an inverse correlation with age. CRSsNP and NENP showed an age‐related increase in type 2 cytokines and a decline in type 3 cytokines. Interestingly, the age‐related decrease in type 3 mediators was associated with those of CT scores in NENP. ENP showed an age‐related increase in type 3 cytokines with type 2 mediators sustained at high levels. Smokers with ENP demonstrated age‐associated increases in type 1/2/3 mediators as well as CT scores. These age‐related patterns in each CRS were confirmed by statistically adjusting atopy status, smoking history, and disease duration. Conclusion: Age‐associated cytokine changes differed among CRS subtypes and control tissues. CRSsNP and NENP demonstrated a decline in type 3 mediators and increase in type 2 mediators, whereas type 3 mediators increased with age in ENP.