Thinned young apple polysaccharide improves hepatic metabolic disorder in high-fat diet-induced obese mice by activating mitochondrial respiratory functions. (June 2017)

• Record Type: Journal Article
• Authors: Chen, Lei; Yang, Xi; Liu, Run; Liu, Lei; Zhao, Daina; Liu, Jiankang; Guo, Yurong; Long, Jiangang
• Is Part Of: Journal of functional foods. Volume 33(2017)
• Page Start: 396
• Page End: 407
• Publication Date: 2017-06
• Subjects: Ribose (PubChem CID: 77982) -- Rhamnose (PubChem CID: 25310) -- Glucose uronic acid (PubChem CID: 149476) -- Galacturonic acid (PubChem CID: 439215) -- Glucose (PubChem CID: 79025) -- Xylose (PubChem CID: 644160) -- Galactose (PubChem CID: 6036) -- Arabinose (PubChem CID: 66308) -- Fucose (PubChem CID: 17106); Thinned young apple polysaccharide -- High-fat diet -- Hepatic metabolic disorder -- Oxidative stress -- Mitochondrial respiratory function; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2017.03.055
• Languages: English
• ISSNs: 1756-4646

Abstract

Highlights: Thinned young apple polysaccharide (TYAP) was isolated from thinned young apples. TYAP could attenuate obesity-associated oxidative stress. TYAP leads to the activation of mitochondrial respiratory function. TYAP may be a natural antioxidant to prevent hepatic metabolic disorder. Abstract: Apple polysaccharides have been previously demonstrated to have beneficial effects on hepatic metabolic functions. Approximately 1.9 million tons of young apples are thinned and abandoned annually in China, and whether the polysaccharide derived from these thinned young apples has metabolic benefits lacks evidence. Thinned young apple polysaccharide (TYAP) has been investigated in high fat diet (HFD)-induced obese mice for its effect on metabolic disorder. Water-soluble TYAP was isolated from thinned young apples and chemically characterized. TYAP administration at dosages of 400 mg/kg/day and 800 mg/kg/day significantly rescued HFD-induced hepatic metabolic impairment, reduced body weight gain, and ameliorated hepatic oxidative stress induced by HFD. In a palmitate-loaded HepG2 cell model, TYAP protected the cells from palmitate-induced insulin resistance and viability loss, suppressed mitochondrial ROS and improved the mitochondrial respiratory function impaired by palmitate. These findings suggest that TYAP could successfully attenuate obesity-associated hepatic metabolic disorder possibly by activating the hepatic mitochondrial respiratory function.