Management of local or regional non‐nodal disease. Issue 2 (12th December 2018)

• Record Type: Journal Article
• Authors: Racz, Jennifer M.; Block, Matthew S.; Baum, Christian L.; Jakub, James W.
• Other Names: Brady Mary S. guestEditor.; Han Dale guestEditor.; Lowe Michael guestEditor.
• Is Part Of: Journal of surgical oncology. Volume 119:Issue 2(2019)
• Page Start: 187
• Page End: 199
• Publication Date: 2018-12-12
• Subjects: diphenylcyclopropenone -- in transit -- intralesional therapy -- limb perfusion -- melanoma, stage III -- talimogene laherparepvec; Cancer -- Surgery -- Periodicals; Neoplasms -- Periodicals; 616
• DOI: 10.1002/jso.25330
• Languages: English
• ISSNs: 0022-4790

Abstract

Abstract : Some melanomas develop a striking avidity for lymphatic spread. In spite of multiple recurrences, patients can remain years without visceral metastasis. There is clearly a biologic reason for this lymphotrophic pattern of growth and dissemination, which we have yet to uncover. In‐transit metastases have widely diverse clinical presentations and can be a stubborn disease to cure. As a result, a host of treatments exist that should be tailored to the individual patient.