Antioxidant Properties of Adrenaline in the Presence of Ge‐132. Issue 26 (6th June 2019)

• Record Type: Journal Article
• Authors: Filonova, Galina E.; Nikolaevskaya, Elena N.; Kansuzyan, Artem V.; Krylova, Irina V.; Egorov, Mikhail P.; Jouikov, Viatcheslav V.; Syroeshkin, Mikhail A.
• Other Names: Nifantiev Nikolay E. guestEditor.; Belen'kii Leonid I. guestEditor.; Petrosyan Vladimir A. guestEditor.
• Is Part Of: European journal of organic chemistry. Issue 26(2019)
• Page Start: 4128
• Page End: 4132
• Publication Date: 2019-06-06
• Subjects: Adrenaline -- Antioxidants -- Cyclic voltammetry -- Germanium -- NMR spectroscopy; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201900331
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : Using cyclic voltammetry, UV and 1 H NMR spectroscopy, we have investigated the effect of 2‐carboxyethylgermanium (Ge‐132), the most common germanium‐containing dietary supplement, on the antioxidant activity of adrenaline in aqueous solutions. The complex formed by adrenaline and Ge‐132 is oxidizable at 400 mV more positive potentials compared to non‐coordinated adrenaline which corresponds to its 9 kcal/mol more difficult oxidation. An equilibrium constant of the complex formation was estimated (1300 m – 1 ). It was shown that at the concentrations <10 –3 m the complex Ge‐132‐adrenaline is mostly dissociated to the initial compounds, and the influence of Ge‐132 on the antioxidant properties of adrenaline becomes significant only when the former is in excess. Considering that such concentrations are typical for physiological conditions, this fact can be significant in identifying the mechanism of the biological action of Ge‐132 and its interference with the biological catechols. Abstract : 1 H NMR, CV and UV/Vis data show that adrenaline forms a complex with carboxyethylgermanium Ge‐132 that has significantly reduced antioxidant properties compared to free adrenaline. However, upon dilution of aqueous solutions of this complex to the concentrations of 10 –4 m or lower causes its dissociation, and the effect of Ge‐132 on the antioxidant properties of adrenaline becomes unnoticeable.