Inter k-shell connectivity: a novel computational approach to identify drug targets. (23rd June 2020)

• Record Type: Journal Article
• Authors: Singh, Praveen Kumar
• Is Part Of: International journal of computational biology and drug design. Volume 13:Number 3(2020)
• Page Start: 272
• Page End: 281
• Publication Date: 2020-06-23
• Subjects: centrality lethality rule -- protein networks -- k-shell decomposition -- Mycobacterium; Computational biology -- Periodicals; Drugs -- Design -- Periodicals; 570.285
• Languages: English
• ISSNs: 1756-0756

Abstract

Central lethality rule suggests that hub proteins are the most important and their deletion leads to more damage to biological networks as compared to non-hub proteins. Hub proteins present towards the core of protein-protein interaction (PPI) network are considered to be more important in comparison to proteins at the periphery. The k-shell decomposition method generates k-shell index which indicates the local and global importance of a protein in PPI network. But there is no method till now reported which can differentiate among the proteins with same k-shell index. In this work attempt has been made to add parameter Inter k-shell connectivity to differentiate proteins with same k-shell index and exploring their biological importance.