PH‐Responsive Polymers for Improving the Signal‐to‐Noise Ratio of Hypoxia PET Imaging with [18F]Fluoromisonidazole. Issue 11 (8th June 2020)

• Record Type: Journal Article
• Authors: Goos, Jeroen A. C. M.; Davydova, Maria; Lengkeek, Nigel; Greguric, Ivan; Whittaker, Michael R.; Quinn, John F.; Baell, Jonathan B.; Lewis, Jason S.; Davis, Thomas P.
• Is Part Of: Macromolecular rapid communications. Volume 41:Issue 11(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-06-08
• Subjects: Macromolecules -- Periodicals; Polymers -- Periodicals; Chemistry -- Periodicals; 547.705
• DOI: 10.1002/marc.202070025
• Languages: English
• ISSNs: 1022-1336

Abstract

Abstract : Front Cover : Positron emission tomography (PET) imaging of hypoxia using the radiotracer [ 18 F]FMISO suffers from a poor signal‐to‐noise ratio due to the unwanted uptake and slow clearance of the radiotracer in surrounding non‐hypoxic cells. In article 2000061, Jason S. Lewis, Thomas P. Davis, and co‐workers decrease the uptake in non‐hypoxic cells by delivering the radiotracer using pH‐responsive polymers, which only release the radiotracer in the acidic microenvironment of hypoxic cells. Cover design credit: Memorial Sloan Kettering Cancer Center.