Severe acute respiratory failure due to a multifactorial diffuse alveolar haemorrhage. Issue 3 (8th March 2020)

• Record Type: Journal Article
• Authors: Crisafulli, Ernesto; Burgazzi, Barbara; Majori, Maria; Serra, Walter; Chetta, Alfredo
• Is Part Of: Respirology case reports. Volume 8:Issue 3(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-03-08
• Subjects: Acute respiratory failure -- clopidogrel -- diffuse alveolar haemorrhage -- warfarin; Respiratory organs -- Diseases -- Periodicals; 616.2005
• DOI: 10.1002/rcr2.531
• Languages: English
• ISSNs: 2051-3380

Abstract

Abstract : Diffuse alveolar haemorrhage (DAH) is a life‐threatening syndrome caused by infection, coagulation disorders or autoimmune diseases. We here report the case of an 81‐year‐old male subject affected by a multifactorial DAH, in which the bleeding was related to the administration of clopidogrel and warfarin, both implicated in the context of a polycythaemia. He developed a severe acute respiratory failure treated with a ventilatory support by means of a continuous positive airway pressure (C‐PAP) therapy. An improvement of patient's clinical conditions was observed only after clopidogrel and warfarin discontinuation. Abstract : We here report the case of an 81‐year‐old male subject affected by a multifactorial diffuse alveolar haemorrhage (DAH), in which the bleeding was related to the administration of clopidogrel and warfarin, both implicated in the context of a polycythaemia. He developed a severe acute respiratory failure treated with a ventilatory support by means of a continuous positive airway pressure (C‐PAP) therapy. An improvement of patient's clinical conditions was observed only after clopidogrel and warfarin discontinuation.