Meningococcal disease: A paradigm of type‐IV pilus dependent pathogenesis. (17th March 2020)

• Record Type: Journal Article
• Authors: dos Santos Souza, Isabel; Maïssa, Nawal; Ziveri, Jason; Morand, Philippe C.; Coureuil, Mathieu; Nassif, Xavier; Bourdoulous, Sandrine
• Other Names: Dussurget Olivier guestEditor.
• Is Part Of: Cellular microbiology. Volume 22:Number 4(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-03-17
• Subjects: adhesion -- cell signalling -- Neisseria meningitidis -- pathogenesis -- therapeutic target -- type IV pili -- virulence; Microbiology -- Periodicals; Cytology -- Periodicals; Host-parasite relationships -- Periodicals; Microbiology -- Periodicals; Cells -- Periodicals; Microbiologie -- Périodiques; Microbiologie; Relation hôte-parasite; Cytologie; Cellule; Réponse cellulaire; Ressource Internet (Descripteur de forme); Périodique électronique (Descripteur de forme); 579.05
• DOI: 10.1111/cmi.13185
• Languages: English
• ISSNs: 1462-5814

Abstract

Abstract: Neisseria meningitidis (meningococcus) is a Gram‐negative bacterium responsible for two devastating forms of invasive diseases: purpura fulminans and meningitis. Interaction with both peripheral and cerebral microvascular endothelial cells is at the heart of meningococcal pathogenesis. During the last two decades, an essential role for meningococcal type IV pili in vascular colonisation and disease progression has been unravelled. This review summarises 20 years of research on meningococcal type IV pilus‐dependent virulence mechanisms, up to the identification of promising anti‐virulence compounds that target type IV pili.