Preparing molecularly imprinted nanoparticles of saponins via cooperative imprinting strategy. Issue 11 (19th March 2020)

• Record Type: Journal Article
• Authors: Zhang, Hao; Zhang, Yanan; Wang, Hailing; Wen, Han; Yan, Zhifeng; Huang, Ailan; Bie, Zijun; Chen, Yang
• Is Part Of: Journal of separation science. Volume 43:Issue 11(2020)
• Page Start: 2162
• Page End: 2171
• Publication Date: 2020-03-19
• Subjects: amphiphilic molecules -- mass spectrometry -- molecular imprinting -- sample preparation -- saponins; Separation (Technology) -- Periodicals; Chromatographic analysis -- Periodicals; 543.089
• DOI: 10.1002/jssc.202000019
• Languages: English
• ISSNs: 1615-9306

Abstract

Abstract: Saponin is an important class of natural products with various pharmacological activities. The selective separation of saponins is an essential step before further analysis. Molecular imprinting has been an effective strategy for preparing antibody mimics. However, a facile and efficient imprinting strategy for saponins is still lacking owing to their amphiphilic nature. Herein, we have prepared the saponins imprinted nanoparticles via cooperative imprinting strategy. This new strategy relies on the combination of various non‐covalent interactions (hydrophobic and hydrogen bonding) and covalent boronate affinity interactions. The obtained imprinted nanoparticles could rebind specific saponins from complex matrices with good selectivity, superb tolerance to interference, and fast binding equilibrium. This method was verified to be versatile and facile. Thus, this strategy could greatly facilitate the preparation of imprinted nanoparticles for the specific recognition of saponins.