Double‐blinded, randomized, and controlled study on the effects of canagliflozin after bariatric surgery: A pilot study. (17th March 2020)

• Record Type: Journal Article
• Authors: Kashyap, Sangeeta R.; Kheniser, Karim; Aminian, Ali; Schauer, Philip; Le Roux, Carel; Burguera, Bartolome
• Is Part Of: Obesity science and practice. Volume 6:Number 3(2020)
• Page Start: 255
• Page End: 263
• Publication Date: 2020-03-17
• Subjects: bariatric surgery -- body composition -- canagliflozin -- type 2 diabetes; Obesity -- Periodicals; 616.398005
• DOI: 10.1002/osp4.409
• Languages: English
• ISSNs: 2055-2238

Abstract

Summary: Setting: Bariatric surgery is indicated for patients diagnosed with obesity and type 2 diabetes. Many patients achieve type 2 diabetes remission soon after bariatric surgery. Even though most maintain good glycemic control, remission is not maintained in all patients, and as a result, some patients may relapse. Type 2 diabetes relapse is common in patients who regain weight; weight regain is prevalent 1 to 2 years after surgery. Additional pharmacotherapy may be required to aid bariatric surgery in fostering weight loss and reducing blood glucose levels. Objectives: The purpose of this clinical trial was to determine the effects of canagliflozin in participants who initially achieved type 2 diabetes remission but subsequently relapsed. Methods: The double‐blinded, randomized, and prospective study recruited participants (n = 16) roughly 3 years after bariatric surgery. The participants were followed for 6 months. Results: Body mass index (−1.24 kg/m 2 ) and body weight (−3.7 kg) were significantly reduced with canagliflozin therapy versus placebo. There were improvements in body fat composition as denoted by reductions in android (−3.00%) and truncal (−2.67%) fat. Also, there were differences in blood glucose and hemoglobin A1C at 6 months. Conclusion: After bariatric surgery, canagliflozin improved weight loss and glycemic outcomes in participants with type 2 diabetes. Canagliflozin also facilitated improvements in body fat composition.