Sugary beverage intake and preclinical Alzheimer's disease in the community. Issue 9 (5th March 2017)

• Record Type: Journal Article
• Authors: Pase, Matthew P.; Himali, Jayandra J.; Jacques, Paul F.; DeCarli, Charles; Satizabal, Claudia L.; Aparicio, Hugo; Vasan, Ramachandran S.; Beiser, Alexa S.; Seshadri, Sudha
• Is Part Of: Alzheimer's & dementia. Volume 13:Issue 9(2017)
• Page Start: 955
• Page End: 964
• Publication Date: 2017-03-05
• Subjects: Sugar -- Diet -- Dementia -- Alzheimer's disease -- Framingham Heart Study; Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1016/j.jalz.2017.01.024
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: Introduction: Excess sugar consumption has been linked with Alzheimer's disease (AD) pathology in animal models. Methods: We examined the cross‐sectional association of sugary beverage consumption with neuropsychological ( N = 4276) and magnetic resonance imaging ( N = 3846) markers of preclinical Alzheimer's disease and vascular brain injury (VBI) in the community‐based Framingham Heart Study. Intake of sugary beverages was estimated using a food frequency questionnaire. Results: Relative to consuming less than one sugary beverage per day, higher intake of sugary beverages was associated with lower total brain volume (1–2/day, β ± standard error [SE] = −0.55 ± 0.14 mean percent difference, P = .0002; >2/day, β ± SE = −0.68 ± 0.18, P < .0001), and poorer performance on tests of episodic memory (all P < .01). Daily fruit juice intake was associated with lower total brain volume, hippocampal volume, and poorer episodic memory (all P < .05). Sugary beverage intake was not associated with VBI in a consistent manner across outcomes. Discussion: Higher intake of sugary beverages was associated cross‐sectionally with markers of preclinical AD.