Frontispiece: Ligand Taxonomy for Bioinorganic Modeling of Dioxygen‐Activating Non‐Heme Iron Enzymes. Issue 27 (12th May 2020)

• Record Type: Journal Article
• Authors: Park, Hyunchang; Lee, Dongwhan
• Is Part Of: Chemistry. Volume 26:Issue 27(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-05-12
• Subjects: bioinorganic chemistry -- coordination modes -- ligand design -- non-heme iron -- O−O bond activation -- structure–activity relationships; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.202082761
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : Enzymes have evolved over billions of years to meet specific functional demands. The extraordinary efficiency and selectivity of such biological catalysts continue to inspire the design and synthesis of their small‐molecule surrogates. In the relatively short history of synthetic bioinorganic chemistry, designer ligands have also been evolved from simple classical Werner‐type ligands. As an illustrative example that showcases the design thought process, in their Concept article on page 5916 ff., H. Park and D. Lee build "taxonomic trees" for the synthetic mimics of O2 ‐activating non‐heme iron enzymes. Primary emphasis is placed on how the combination of ligand donor groups, denticity, and backbone topology collectively dictate the coordination chemistry of the metal center of immediate relevance to the oxidation/oxygenation reactivity.