Chalcone hybrids and their antimalarial activity. Issue 4 (31st January 2020)

• Record Type: Journal Article
• Authors: Cheng, Peng; Yang, Linlin; Huang, Xiaodan; Wang, Xuejun; Gong, Maoqing
• Is Part Of: Archiv der Pharmazie. Volume 353:Issue 4(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-01-31
• Subjects: antimalarial -- antiplasmodial -- chalcone -- hybrid compounds -- structure–activity relationship; Pharmaceutical chemistry -- Periodicals; Pharmacology -- Periodicals; 615.19
• DOI: 10.1002/ardp.201900350
• Languages: English
• ISSNs: 0365-6233

Abstract

Abstract: Malaria, one of the most striking, re‐emerging infectious diseases caused by the genus Plasmodium, places a huge burden on global healthcare systems. A major challenge in the control and eradication of malaria is the continuous emergence of increasingly widespread drug‐resistant malaria, creating an urgent need to develop novel antimalarial agents. Chalcone derivatives are ubiquitous in nature and have become indispensable units in medicinal chemistry applications due to their diverse biological profiles. Many chalcone derivatives demonstrate potential in vitro and in vivo antimalarial activity, so chalcone could be a useful template for the development of novel antimalarial agents. This review covers the recent development of chalcone hybrids as antimalarial agents. The critical aspects of the design and structure–activity relationship of these compounds are also discussed. Abstract : A major challenge in the control of malaria is the continuous emergence of drug‐resistance, creating an urgent need to develop novel antimalarial agents. This review covers the recent development of chalcone hybrids as antimalarial agents. The critical aspects of the design and structure–activity relationship of these compounds are also discussed.