Analysis of heart injury laboratory parameters in 273 COVID‐19 patients in one hospital in Wuhan, China. Issue 7 (15th April 2020)

• Record Type: Journal Article
• Authors: Han, Huan; Xie, Linlin; Liu, Rui; Yang, Jie; Liu, Fang; Wu, Kailang; Chen, Lang; Hou, Wei; Feng, Yong; Zhu, Chengliang
• Other Names: Luo Guangxiang (George) guestEditor.; Gao Shou‐Jiang guestEditor.
• Is Part Of: Journal of medical virology. Volume 92:Issue 7(2020)
• Page Start: 819
• Page End: 823
• Publication Date: 2020-04-15
• Subjects: COVID‐19 -- disease severity -- heart injury -- laboratory indicators; Virology -- Periodicals; 616
• DOI: 10.1002/jmv.25809
• Languages: English
• ISSNs: 0146-6615

Abstract

Abstract: An outbreak of severe acute respiratory syndrome novel coronavirus (SARS‐CoV‐2) epidemic spreads rapidly worldwide. SARS‐CoV‐2 infection caused mildly to seriously and fatally respiratory, enteric, cardiovascular, and neurological diseases. In this study, we detected and analyzed the main laboratory indicators related to heart injury, creatine kinase isoenzyme‐MB (CK‐MB), myohemoglobin (MYO), cardiac troponin I (ultra‐TnI), and N‐terminal pro‐brain natriuretic peptide (NT‐proBNP), in 273 patients with COVID‐19 and investigated the correlation between heart injury and severity of the disease. It was found that higher concentration in venous blood of CK‐MB, MYO, ultra‐TnI, and NT‐ proBNP were associated with the severity and case fatality rate of COVID‐19. Careful monitoring of the myocardiac enzyme profiles is of great importance in reducing the complications and mortality in patients with COVID‐19. Highlights: The blood tests of patients on admission showed some patients had higher levels of CK‐MB, MYO, ultra‐TnI and NT‐proBNP. Increased concentration in venous blood of MYO, ultra‐TnI and NT‐proBNP were associated with the severity of COVID‐19. All four parameters were significantly higher in the death than in the alive group.