Post‐translational modifications of protein in response to ionizing radiation. (14th January 2020)

• Record Type: Journal Article
• Authors: Liu, Xiaodong; Liu, Rui; Bai, Yongheng; Jiang, Heya; Fu, Xinxin; Ma, Shumei
• Is Part Of: Cell biochemistry and function. Volume 38:Number 3(2020)
• Page Start: 283
• Page End: 289
• Publication Date: 2020-01-14
• Subjects: acetylation -- glycosylation -- ionizing radiation -- methylation -- phosphorylation -- post‐translational modifications -- ubiquitination; Cytochemistry -- Periodicals; Cell metabolism -- Periodicals; Biochemistry -- Periodicals; Cytology -- Periodicals; 572
• DOI: 10.1002/cbf.3467
• Languages: English
• ISSNs: 0263-6484

Abstract

Abstract : Based on central dogma of genetics, protein is the embodiment and executor of genetic function, post‐translational modifications (PTMs) of protein are particularly important and involved in almost all aspects of cell biology and pathogenesis. Studies have shown that ionizing radiation (IR) alters gene expression much more profoundly and a broad variety of cell‐process pathways, lots of proteins are modified and activated. Our understanding of the protein in response to ionizing radiation is steadily increasing. Among the various biological processes known to induce radioresistance, PTMs have attracted marked attention in recent years. The present review summarizes the latest knowledge about how PTMs response to ionizing radiation and pathway analysis were conducted. The data provided insights into biological effects of IR and contributing to the development of novel IR‐based strategies.