Copper‐Catalyzed Enantioselective Cyano(Fluoro)Alkylation of Alkenes. Issue 11 (18th May 2020)

• Record Type: Journal Article
• Authors: Israr, Muhammad; Xiong, Haigen; Li, Yajun; Bao, Hongli
• Is Part Of: Advanced synthesis & catalysis. Volume 362:Issue 11(2020)
• Page Start: 2211
• Page End: 2215
• Publication Date: 2020-05-18
• Subjects: Copper catalysis -- Asymmetric cyanofluoroalkylation -- Radical reaction -- Difunctionalization of alkenes; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202000230
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A copper‐catalyzed asymmetric cyano(fluoro)alkylation reaction of alkenes is reported. A range of chiral fluoroalkyl cyanides were obtained in high yields and excellent enantiomeric excess from readily available chemicals. The method uses fluoroalkyl iodides as the fluoroalkyl source and employs mild conditions. The peroxide LPO plays a significant role in promotion of this radical asymmetric reaction. Abstract :