Adjuvants that Empower the Action of Photodynamic Therapy. (11th April 2020)

• Record Type: Journal Article
• Authors: Ortel, Bernhard; Jabeen, Shakeela; Greer, Alexander
• Other Names: Hasan Tayyaba guestEditor.; Kessel David guestEditor.; Greer Alexander guestEditor.
• Is Part Of: Photochemistry and photobiology. Volume 96:Number 3(2020)
• Page Start: 725
• Page End: 727
• Publication Date: 2020-04-11
• Subjects: Photochemistry -- Periodicals; Light -- Physiological effect -- Periodicals; 541.35
• DOI: 10.1111/php.13235
• Languages: English
• ISSNs: 0031-8655

Abstract

Abstract: Compounds have been devised whose supportive actions make them important adjuvants in the priming of photosensitization to selectively target cancer cells. Here, we highlight the paper by Maytin and Hasan in this issue of Photochemistry & Photobiology, which describes adjuvants methotrexate, 5‐fluorouracil, vitamin D and its analogs leading to improved photodynamic therapy outcome. These small molecule adjuvants act by different mechanisms to enhance the cytotoxicity in tumor cells and the therapeutic effect in cancers. These findings add to the list of strategies for enhancement of photodynamic therapy. Abstract : Progress is still needed before small molecule adjuvants, including re‐purposed chemotherapeutic drugs and vitamin D that enhance photodynamic therapy can be used in routine clinical applications. The mechanism includes enhanced conversion of exogenous ALA and thus increased protoporphyrin IX concentrations. Adjuvant pretreatment improves not only fluorescent imaging but also the cells' susceptibility to lethal photosensitization.