Oesophagobronchial perforations after placement of an oesophageal self‐expanding metallic stent. Issue 4 (7th April 2020) - Tomiyama, Ken‐ichi
Abstract: An oesophageal fully covered self‐expanding metallic stent (SEMS) was placed in a 54‐year‐old Japanese man to relieve dysphagia owing to a stage cT1bN3M1c lung adenocarcinoma. High expression of programmed cell death‐ligand 1 was microscopically confirmed, and pembrolizumab was subsequently administered. Several days later, the patient was hospitalized with septic shock, and severe mediastinitis and pneumonia caused by oesophageal SEMS‐induced oesophageal and bronchial perforations were observed. Thoracoscopic surgery was performed to drain the mediastinal abscess, and an additional oesophageal SEMS was placed to close the oesophageal perforation. The patient gradually recovered from the potentially fatal infection, and the SEMS was retrieved after confirming perforation closure. We re‐initiated pembrolizumab administration, and the patient responded well. The present report reveals the potential risk and effectiveness of SEMS, especially when administered with immune checkpoint inhibitors. Abstract : An oesophageal fully covered self‐expanding metallic stent was inserted in a patient with advanced lung adenocarcinoma. After administration of pembrolizumab, he was hospitalized with septic shock caused by oesophagobronchial perforations. Owing to a drainage surgery and insertion of additional stents, he was recovered and pembrolizumab administration was re‐initiated with complete resolution.