Aminobisphosphonate‐treated ewes as a model of osteonecrosis of the jaw and of dental implant failure. Issue 5 (15th December 2019)

• Record Type: Journal Article
• Authors: Davison, Mario R.; Lyardet, Leonardo; Preliasco, Mariana; Yaful, Graciela; Torres, Perla; Bonanno, Marina S.; Pellegrini, Gretel G.; Zeni, Susana N.
• Is Part Of: Journal of periodontology. Volume 91:Issue 5(2020)
• Page Start: 628
• Page End: 637
• Publication Date: 2019-12-15
• Subjects: bisphosphonate‐associated osteonecrosis of the jaw -- dental implants -- metabolic bone diseases -- osteoporosis -- zoledronic acid; Periodontics -- Periodicals; 617.632
• DOI: 10.1002/JPER.19-0213
• Languages: English
• ISSNs: 0022-3492

Abstract

Abstract: Background: Bisphosphonate (BP)‐related osteonecrosis of the jaw (BRONJ) and dental implant failure are two negative side effects of chronic aminoBP treatment. Methods: Eleven ovariectomized (OVX) ewes and four ewes subjected to sham surgery (SHAM) were treated as follows: OVX ( n = 5): OVX plus saline solution; zoledronic acid‐treated group (ZOL) ( n = 6): OVX plus ZOL; SHAM ( n = 4): SHAM plus saline solution. Extraction of the first upper molar was performed at 1 year, dental implant placement at 2 years, and sacrifice at 28 months. Results: Implants remained in place in SHAM and OVX ewes but were lost in all ZOL ewes. ZOL sheep (2/6) showed inflammation and necrotic bone at mandibular region. No differences in serum calcium (Ca), inorganic phosphate (Pi) or 25‐hydroxyvitamin D were observed, whereas bone alkaline phosphatase levels decreased in the three studied groups ( P < 0.05). The significantly lowest levels of carboxy‐terminal telopeptide of type I collagen were observed in ZOL ( P < 0.05), and showed no differences between SHAM and OVX. OVX showed the lowest and ZOL the highest Ca and Pi contents in femur and maxilla ( P < 0.05). Bone volume (BV/TV%) and iliac crest were similar at baseline and at month 4. At the end of the study, BV/TV%, proximal femur and hemi‐mandible bone mineral content and bone mineral density, and trabeculae number were similar in SHAM and ZOL, and lower in OVX ( P < 0.05). Conclusion: All ZOL‐treated ewes on a schedule similar to that used in cancer patients showed extensive suppression of bone remodeling and implant failure. Some of the ZOL ewes developed BRONJ.