Size and Shape Effects of Near‐Infrared Light‐Activatable Cu2(OH)PO4 Nanostructures on Phototherapeutic Destruction of Drug‐Resistant Hypoxia Tumors. (20th April 2020)

• Record Type: Journal Article
• Authors: Nuthalapati, Karthik; Vankayala, Raviraj; Chiang, Chi‐Shiun; Hwang, Kuo Chu
• Is Part Of: Particle and particle systems characterization. Volume 37:Number 5(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-04-20
• Subjects: hypoxia -- nanomaterial‐mediated photodynamic therapy -- near‐infrared light -- reactive oxygen species; Particles -- Periodicals; 620.43
• DOI: 10.1002/ppsc.202000001
• Languages: English
• ISSNs: 0934-0866

Abstract

Abstract: Development of simple, robust, and noninvasive therapeutic approaches to treat cancers and improve survival rates is a grand challenge in clinical biomedicine. In particular, the sizes and shape of the nanomaterials play a vital role in dictating their biodistribution and clearance pathways. It remains elusive how the size and shape of a nanomaterial affect its therapeutic efficacy in cancer diagnosis and treatments. To tackle the above problem, the effects of size and shape of Cu2 (OH)PO4 nanostructures (nanosheets and quantum dots) on the photodynamic therapy (PDT) in destroying malignant drug‐resistant lung tumors and on combating the tumor hypoxia problem are investigated and compared. The photocatalytic mechanism of Cu2 (OH)PO4 nanostructures mainly involves the generation of reactive oxygen species (ROS), such as hydroxyl radical ( · OH) and singlet oxygen ( 1 O2 ). Under an oxygen deprivation condition, Cu2 (OH)PO4 nanosheets still can generate OH radicals to kill cancer cells upon near‐infrared (NIR) light irradiation. Overall, in vitro and in vivo experiments show that Cu2 (OH)PO4 nanosheets can overcome tumor hypoxia problems and effectively mediate dual modal PDT and photothermal therapeutic (PTT) effects on destruction of NCI‐H23 lung tumors in mice using ultralow doses (350 mW cm −2 ) of NIR (915 nm) light. Abstract : The sizes and shape of nanomaterials play a vital role in dictating their biodistribution and clearance pathways. For the first time, the effects of size and shape of Cu2 (OH)PO4 nanostructures (nanosheets and quantum dots) on the efficacies of nanomaterial‐mediated phototherapeutic treatment of malignant drug‐resistant lung tumors and on combating the tumor hypoxia problem are investigated and compared.