Coronary heart disease, heart failure, and the risk of dementia: A systematic review and meta‐analysis. Issue 11 (26th February 2018)

• Record Type: Journal Article
• Authors: Wolters, Frank J.; Segufa, Reffat A.; Darweesh, Sirwan K.L.; Bos, Daniel; Ikram, Mohammad Arfan; Sabayan, Behnam; Hofman, Albert; Sedaghat, Sanaz
• Is Part Of: Alzheimer's & dementia. Volume 14:Issue 11(2018)
• Page Start: 1493
• Page End: 1504
• Publication Date: 2018-02-26
• Subjects: Coronary heart disease -- Myocardial infarction -- Heart failure -- Dementia -- Alzheimer's disease; Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1016/j.jalz.2018.01.007
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: Introduction: Cardiovascular risk factors are closely linked with dementia risk, but whether heart disease predisposes to dementia is uncertain. Methods: We systematically reviewed the literature and meta‐analyzed risk estimates from longitudinal studies reporting the association of coronary heart disease (CHD) or heart failure (HF) with risk of dementia. Results: We identified 16 studies (1, 309, 483 individuals) regarding CHD, and seven studies (1, 958, 702 individuals) about HF. A history of CHD was associated with a 27% increased risk of dementia (pooled relative risk [RR] [95% confidence interval, CI]: 1.27 [1.07–1.50]), albeit with considerable heterogeneity across studies (I 2 = 80%). HF was associated with 60% increased dementia risk (pooled RR 1.60 [1.19–2.13]) with moderate heterogeneity (I 2 = 59%). Among prospective population‐based cohorts, pooled estimates were similar (for CHD, RR 1.26 [1.06–1.49], nine studies; and HF, RR 1.80 [1.41–2.31], four studies) and highly consistent (I 2 = 0%). Conclusion: CHD and HF are associated with an increased risk of dementia.