Platelet recovery correlates parenchymal volume recovery after liver resection. Issue 5 (3rd February 2020)

• Record Type: Journal Article
• Authors: Yamazaki, Shintaro; Takayama, Tadatoshi; Mitsuka, Yusuke; Aoki, Masaru; Midorikawa, Yutaka; Moriguchi, Masamichi; Higaki, Tokio
• Is Part Of: Hepatology research. Volume 50:Issue 5(2020)
• Page Start: 620
• Page End: 628
• Publication Date: 2020-02-03
• Subjects: liver ischemia -- liver regeneration -- platelet count; Liver -- Diseases -- Periodicals; Liver Diseases -- Periodicals; Foie -- Maladies -- Périodiques; 616.362
• DOI: 10.1111/hepr.13488
• Languages: English
• ISSNs: 1386-6346

Abstract

Abstract : Aim: Platelet count seems to assess liver function and predict liver regeneration, but factors associated with liver regeneration remain unclear. This study analyzed the relationship between platelet recovery and postresection liver regeneration. Methods: Data from 343 candidates from 1245 consecutive patients with liver resection of more than Couinaud's segments were analyzed. Patients were divided into a low‐platelet‐recovery rate (LPRR) group (lowest 25%) or a control group on the basis of the platelet recovery rate on postoperative day (POD)7. Data were matched before analysis to adjust for operation scale. Trends in liver functional recovery were assessed, and liver volume recovery and remnant ischemic area was calculated using computed tomography volumetry. Factors predicting liver regeneration were analyzed. Results: In 78 matched‐pair patients, the all‐complications rate (42.3% vs. 26.9%, P = 0.002) and infectious complications rate (21.8% vs. 9.0%, P = 0.027) were significantly higher in the LPRR group than in controls. Trends in liver functional recovery did not differ significantly, whereas significant differences remained for platelet recovery. Parenchyma volume recovery was delayed in the LPRR group from POD7 (84.5% vs. 78.1, P < 0.01) to POD30 (92.5% vs. 85.6, P < 0.01). Platelet recovery rate on POD7 correlated negatively with ischemic liver volume as evaluated on POD2 by computed tomography (r = 0.691). Postoperative ischemic volume on POD2 (5.41 [1.98–11.21], P < 0.001), infectious complications (3.48 [1.44–7.37], P < 0.001), and multiple resection (1.67 [1.10–4.11], P = 0.011) predicted delayed platelet recovery rate on multivariate analysis. Conclusion: Platelet recovery correlated with liver volume recovery and occurrence of complications. Large ischemic area might negatively impact regeneration after liver resection.