Enzyme Responsive Inverse Opal Hydrogels. Issue 5 (31st January 2020)

• Record Type: Journal Article
• Authors: Pei, Yi; Molley, Thomas G.; Kilian, Kristopher A.
• Is Part Of: Macromolecular rapid communications. Volume 41:Issue 5(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-01-31
• Subjects: biodegradable -- biomaterials -- biomimetic materials -- enzymes -- hydrogel; Macromolecules -- Periodicals; Polymers -- Periodicals; Chemistry -- Periodicals; 547.705
• DOI: 10.1002/marc.201900555
• Languages: English
• ISSNs: 1022-1336

Abstract

Abstract: Structured color in nature is controlled by nano‐ and micro‐structured interfaces giving rise to a photonic bandgap. This study presents a biomimetic optical material based on polymeric inverse opals that respond to enzyme activity. Polymer colloids provide a template in which acryloyl‐functionalized poly(ethylene glycol) is integrated; dissolution of the colloids leads to a hydrogel inverse opal that can be lithographically patterned using transfer printing. Incorporating enzyme substrates within the voids provides a material that responds to the presence of proteases through a shift in the optical properties. Abstract : A polymeric inverse opal hydrogel that responds to enzyme activity is presented in this communication. Acryloyl‐functionalized poly(ethylene glycol)‐based inverse opal hydrogel can be made by templating against closely packed colloids. Incorporating enzyme substrates within the voids provides a material that responds to the presence of proteases through a shift in the optical properties.