Can we prevent Alzheimer's disease? Secondary "prevention" trials in Alzheimer's disease. Issue 2 (14th February 2013)

• Record Type: Journal Article
• Authors: Carrillo, Maria C.; Brashear, H. Robert; Logovinsky, Veronika; Ryan, J. Michael; Feldman, Howard H.; Siemers, Eric R.; Abushakra, Susan; Hartley, Dean M.; Petersen, Ronald C.; Khachaturian, Ara S.; Sperling, Reisa A.
• Is Part Of: Alzheimer's & dementia. Volume 9:Issue 2(2013)
• Page Start: 123
• Page End: 131.e1
• Publication Date: 2013-02-14
• Subjects: Alzheimer's disease -- Prevention -- Diagnosis -- Mild cognitive impairment -- Preclinical Alzheimer's; Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1016/j.jalz.2012.12.004
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract : Current research including the basic biology of Alzheimer's disease (AD) provides a foundation to explore whether our current state of knowledge is sufficient to initiate prevention studies and allow us to believe prevention of AD is possible. Current research and recently revised criteria for the diagnosis of AD by the National Institutes on Aging and the Alzheimer's Association suggest a continuum of disease from preclinical asymptomatic to symptomatic Alzheimer's dementia. In light of these revised criteria, the possibility of secondary prevention and even primary prevention is under discussion. The Alzheimer's Association Research Roundtable convened a meeting to discuss the rationale and feasibility of conducting secondary prevention trials in AD.