Simultaneous edited MRS of GABA, glutathione, and ethanol. (14th January 2020)
- Record Type:
- Journal Article
- Title:
- Simultaneous edited MRS of GABA, glutathione, and ethanol. (14th January 2020)
- Main Title:
- Simultaneous edited MRS of GABA, glutathione, and ethanol
- Authors:
- Saleh, Muhammad G.
Wang, Min
Mikkelsen, Mark
Hui, Steve C.N.
Oeltzschner, Georg
Boissoneault, Jeff
Stennett, Bethany
Edden, Richard A.E.
Porges, Eric C. - Abstract:
- Abstract : The aim of this work was to develop simultaneous edited MRS of γ‐aminobutyric acid (GABA), glutathione (GSH), and ethanol (EtOH) using Hadamard encoding and reconstruction of MEGA‐edited spectroscopy (HERMES) at 3T. Density‐matrix simulations of HERMES were carried out and compared with phantom experiments. In vivo experiments were performed in six healthy volunteers about 30 min after alcohol consumption. Simulations of HERMES showed GABA‐, GSH‐, and EtOH‐edited spectra with low levels of crosstalk and excellent agreement with phantom spectra. In vivo experiments showed well edited GABA signals at 3.0 ppm, GSH at 2.95 ppm, and EtOH at 1.18 ppm in the respective Hadamard combination spectra. Measured integral ratios were 0.082 ± 0.012 for GABA/Cr, 0.037 ± 0.006 for GSH/Cr, and 0.305 ± 0.129 for EtOH/Cr. Simulated, phantom, and in vivo measurements of HERMES show excellent separation of GABA‐, GSH‐, and EtOH‐edited signals with negligible levels of crosstalk. HERMES allows a threefold acceleration of editing while maintaining spectral quality compared with sequentially acquired MEGA‐PRESS measurements. Abstract : We demonstrate simultaneous edited MRS of γ‐aminobutyric acid (GABA), glutathione (GSH), and ethanol (EtOH) using Hadamard encoding and reconstruction of MEGA‐edited spectroscopy (HERMES) at 3T. HERMES allows threefold acceleration of editing while maintaining spectral quality compared with sequentially acquired MEGA‐PRESS measurements.
- Is Part Of:
- NMR in biomedicine. Volume 33:Number 4(2020)
- Journal:
- NMR in biomedicine
- Issue:
- Volume 33:Number 4(2020)
- Issue Display:
- Volume 33, Issue 4 (2020)
- Year:
- 2020
- Volume:
- 33
- Issue:
- 4
- Issue Sort Value:
- 2020-0033-0004-0000
- Page Start:
- n/a
- Page End:
- n/a
- Publication Date:
- 2020-01-14
- Subjects:
- edited MRS -- ethanol -- GABA -- GSH -- HERMES
Nuclear magnetic resonance -- Periodicals
Magnetic Resonance Spectroscopy -- Periodicals
574 - Journal URLs:
- http://onlinelibrary.wiley.com/ ↗
- DOI:
- 10.1002/nbm.4227 ↗
- Languages:
- English
- ISSNs:
- 0952-3480
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 6113.931000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 13170.xml